Last updated October 21, 2026. Approval line checked October 21, 2026. No compounding source date is assigned.
FDA status
Not approved
Not approved. This record is not an FDA-approved drug product. Approval, where it exists, is specific to a drug product, indication, and route.
FDA: Unapproved drugsBy signing up you agree to get PeptideX update emails. Unsubscribe anytime. Educational only, not medical advice.
Evidence tier
Animal Only. The tier is the highest indexed study type. It is not a safety rating and it is not an FDA approval. Confidence score 3/5. 15 PubMed citations indexed.
PE-22-28 is a synthetic 7-amino-acid fragment derived from the sortilin propeptide (spadin/PE 12-28) that selectively inhibits TREK-1 two-pore domain potassium channels with an IC50 of ~0.12 nM, enhan
What the literature studies
Cognitive Research
Evidence tier
Animal Only
Compounding record
Status not verified
Status not verified. No product-specific FDA primary source is recorded for this entry. FDA approval and compounding eligibility are not verified. Research information is not evidence of FDA approval. Approval, where applicable, is specific to a drug product, indication and route. Research information is not evidence of FDA approval. Approval, where applicable, is specific to a drug product, indication and route.
Regulatory source not verified; no checked date is assigned.
All evidence is preclinical rodent data; no human pharmacokinetics, safety data, or clinical trials exist for PE-22-28.
By signing up you agree to get PeptideX update emails. Unsubscribe anytime. Educational only, not medical advice.
Educational only. Not medical advice. This page does not give doses or sourcing. See the medical and editorial disclaimer.