Ginsenoside Rg3 (RG3)

Last updated October 21, 2026. Approval line checked October 21, 2026. No compounding source date is assigned.

FDA status

Not approved

Not approved. This record is not an FDA-approved drug product. Approval, where it exists, is specific to a drug product, indication, and route.

FDA: Unapproved drugs

Evidence tier

Human Observational. The tier is the highest indexed study type. It is not a safety rating and it is not an FDA approval. Confidence score 3/5. 915 PubMed citations indexed.

Ginsenoside Rg3 (RG3) in the literature

Ginsenoside Rg3 is a steroidal saponin triterpenoid from Panax ginseng with peptide-adjacent pharmacology that modulates multiple signaling pathways including NF-κB suppression, Nrf2 activation for an

What the literature studies

Immune Research

Evidence tier

Human Observational

Compounding record

Status not verified

Confidence
3/5

Regulatory record

Status not verified. No product-specific FDA primary source is recorded for this entry. FDA approval and compounding eligibility are not verified. Research information is not evidence of FDA approval. Approval, where applicable, is specific to a drug product, indication and route. Research information is not evidence of FDA approval. Approval, where applicable, is specific to a drug product, indication and route.

Regulatory source not verified; no checked date is assigned.

RG3 is a non-peptide triterpenoid saponin categorized as 'peptide-adjacent'; its extremely poor oral bioavailability (<5%) means most supplemental forms provide minimal systemic ex

Questions

Educational only. Not medical advice. This page does not give doses or sourcing. See the medical and editorial disclaimer.