LongevityNot approvedEvidence tier: Animal Only

FOXO4-DRI

Last updated October 21, 2026. Approval line checked October 21, 2026. No compounding source date is assigned.

FDA status

Not approved

Not approved. This record is not an FDA-approved drug product. Approval, where it exists, is specific to a drug product, indication, and route.

FDA: Unapproved drugs

Evidence tier

Animal Only. The tier is the highest indexed study type. It is not a safety rating and it is not an FDA approval. Confidence score 1/5. 85 PubMed citations indexed.

FOXO4-DRI in the literature

D-amino acid retro-inverso peptide disrupting FOXO4-p53 interaction in senescent cells, triggering apoptosis selectively in senescent cells while sparing healthy tissue.

What the literature studies

Senolytic Therapy

Evidence tier

Animal Only

Compounding record

Status not verified

Confidence
1/5

Regulatory record

Status not verified. No product-specific FDA primary source is recorded for this entry. FDA approval and compounding eligibility are not verified. Research information is not evidence of FDA approval. Approval, where applicable, is specific to a drug product, indication and route. Research information is not evidence of FDA approval. Approval, where applicable, is specific to a drug product, indication and route.

Regulatory source not verified; no checked date is assigned.

Entirely preclinical; no human safety data; mechanism involves direct apoptosis induction with unclear off-target effects.

Questions

Educational only. Not medical advice. This page does not give doses or sourcing. See the medical and editorial disclaimer.